Keywords: Apremilast.svg Skeletal formula of apremilast Created using http //www acdlabs com/download/chemsk html ACD/ChemSketch 10 0 Inkscape and vim Own work after cite journal Man HW Schafer P Wong LM et al Discovery of S -N-1- 3-ethoxy-4-methoxyphenyl -2-methanesulfonylethyl-1 3-dioxo-2 3-dihydro-1H-isoindol-4-yl acetamide apremilast a potent and orally active phosphodiesterase 4 and tumor necrosis factor-alpha inhibitor J Med Chem 52 6 1522 “4 2009 March PMID 19256507 10 1021/jm900210d 2009-04-27 Fvasconcellos Apremilast |