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| Keywords: CCL3L1-CCR5 Genotype Improves the Assessment of AIDS Risk in HIV-1-Infected Individuals -Figure 3.png CCL3L1-CCR5 GRGs influence median time-from-seroconversion to CD4 cell count thresholds that might be used to guide initiation of HAART and time from a high to a low CD4 cell count In Panel A KM plots show the time-from-seroconversion to arrival at <450 left <350 center or <200 right CD-cells/mm3 In Panel B the KM plots are for progression from <450 to <200 CD4-cells/mm3 in all seroconverters left or seroconverters recruited and followed during the years 1990 to 1999 a time-period in which antiretroviral therapy was available right The color codes for the KM plots in panel B are blue low GRG; brown moderate and high GRGs combined into a single category; and black all subjects Overall P values are at the top of each plot Color-coded numbers at the upper right of the KM plots represent the median time-to-event that is from seroconversion to the indicated CD4 cell count In panel A P values for differences in median time-to-event relative to those with a low GRG were 0 1131; 0 0089; ¡ 0 0030; § 0 0005; ¶ 0 0001; and ˆ¥ 9 6×10 ˆ’7 RH relative hazard; CI confidence interval P values in Panel B are adjusted for the steady-state viral load baseline CD4 and best DTH response recorded during disease course and subjects with a moderate or high GRG were combined into a single category Uploaded for use in s CCL3L1-CCR5 Genotype Improves the Assessment of AIDS Risk in HIV-1-Infected Individuals http //www plosone org/article/info 3Adoi 2F10 1371 2Fjournal pone 0003165 Sept 08 Hemant Kulkarni Brian K Agan Vincent C Marconi Robert J O'Connell Jose F Camargo Weijing He Judith Delmar Kenneth R Phelps George Crawford Robert A Clark Matthew J Dolan Sunil K Ahuja This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that once placed in the public domain this work may be freely reproduced distributed transmitted modified built upon or otherwise used by anyone for any lawful purpose cc-pd AIDS Genotypes | ||||
