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| Keywords: Nodal signaling.jpg of the Nodal signaling pathway own Sofia mr007 2010-04-04 Signaling pathways Developmental biology ImageNote 1 434 568 452 110 1168 1198 2 Ectodermin PPM1A XFDR and Tgf1 negative regulate the pathway by competing with Smad components or transcription factors ImageNoteEnd 1 ImageNote 2 462 736 358 186 1168 1198 2 The protein expression levels of Nodal and Lefty are affected due to the activity of the miR-430 super-family ImageNoteEnd 2 ImageNote 3 436 966 458 210 1168 1198 2 The interaction of Nodal with BMPs BMP3 BMP7 Lefty or with Cerberus in the outside of the cells affects its capability to bind to the receptors and reactivate the signal ImageNoteEnd 3 ImageNote 4 406 10 260 196 1168 1198 2 Once the protein is translated it has to be processed in the extracellular space by Convertases Furin and PACE4 Mature Nodal binds to the Activin receptors I and II and the co-rreceptor Cripto/Cryptic and phosphorilates Smad2 /3 ImageNoteEnd 4 ImageNote 5 410 264 518 270 1168 1198 2 Phospho-Smad2 /3 form a complex with Smad4 and enter into the nucleus ImageNoteEnd 5 ImageNote 6 292 146 116 94 1168 1198 2 Dapper2 targets the Activin Receptor Type I for lysosomal degradation ImageNoteEnd 6 | ||||
