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PKM2 plays key roles in reprogramming cancer cells from energy production to growth (Warburg Effect). The dimeric form of the enzyme is not only less active in glycolysis but can also move into the nucleus to promote the transcription of other cancer-causing genes. A substrate analogon (red) is bound to the active site. PKM2 is a target for anti-cancer therapies. PDB entry: 6WP3.
Antibodies conjugated with drugs at the FC region are designed to attach a drug to the FC region of the antibody. This technology leverages the specificity of antibodies to deliver the drug directly to target cells. As a result, it can enhance the drug's effectiveness and reduce side effects. This approach is particularly promising in cancer treatment and therapies for autoimmune diseases.
3D cartoon and Gaussian surface models, PDB 6vg8, white background
A ball-and-stick molecular model of the hormone Orexin, also known as Hypocretin. Orexin is involved in the regulation of the sleep/wake cycle and it stimulates apetite, wakefulness and energy expenditure. It has been linked with Alzheimer's disease. Isolated on white.
c-Myc and Max transcription factors bound to DNA. 3D illustration. Atoms shown as spheres with conventional color coding.
DNA A-T Pair
Cytochrome P450 molecule. CYP 3A4 is the most promiscuous of the human CYP enzymes. Molecular model. 3D rendering. Illustration
Rendered coronavirus/2019-nCoV single-stranded RNA, built from experimentally determined Ebola virus crystal structure. Color symbols - bluewhite=carbon, pink=oxygen, lightblue=nitrogen, white=hydrogen, lavender=phosphorus
Avibactam is a diazobicyclooctane inhibitor of gram-negative and gram-positive bacteria. Avibactam (red) inhibits the bacterial enzyme beta-lactamase (blue) of Clostridioides difficile.
Colorful Molecules Background
3D cartoon and Gaussian surface models, chain id color scheme, PDB 5y0m, white background
A ball and stick + ribbons model of HIV protease - an enzyme that is the target of much AIDS and HIV research.
Botulinum toxin neurotoxic protein, 3D rendering. Produced by Clostridium botulinum. Cosmetically used to treat wrinkles.
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Cholera toxin, molecular model. Cholera toxin (choleragen) is a protein complex secreted by the bacterium Vibrio cholerae, that causes the disease cholera. It is made up of a wedge-shaped A subunit (right part of illustration) and five B subunits (left part of illustration) that form a ring which binds to the intestinal lining. In its most severe forms, cholera is one of the most rapidly fatal illnesses known.
A molecule of sucrose, showing thermal ellipsoids.
PETase (left) degrades polyethylene terephtalate (PET) into monohydroxyethyl terephthalate (MHET) and MHETase degrades MHET ethylene glycol (EG) and terephthalic acid (TPA). The substrates in the binding sites are depicted in red.
3D cartoon and Gaussian surface models. PDB 3kqg, chain id color scheme, white background.
A space-filling molecular model of collagen, a fibrous protein that provides structural support in animals. It has a distinctive triple helix structure. Isolated on black.
Glucose-6-phosphate dehydrogenase (G6PD) protein. Enzyme of the pentose phosphate pathway that generates co-enzyme NADPH. 3D illustration.
molecular model of Sovaldi (generic name: Sofosbuvir), the most popular drug to treat hepatitis C infection
Beta-alanine or β-Alanine molecule. It is naturally occurring beta amino acid. Molecular model. 3D rendering. Illustration
Scientific background. 3D render.
Abstract Pink And Green Knot
Multi-colored connected spheres building a molecular structure.
3D cartoon and Gaussian surface models, PDB 1j7n, chain id color scheme, white background
A ball and stick model of a molecule of Human Glucagon, a hormone produced in the pancreas and used by the body to raise levels of glucose in the blood. Glucagon worksin the opposite manner to Insulin, which lowers levels of glucose in the blood - together they work to keep glucose levels stable.
Indoleamine 2,3 dioxygenase 1 (IDO1) protein. Tryptophan catabolic enzyme of the kynurenine pathway. 3D illustration.
Molecular model of Adenosine triphosphate, or Adenosine-5'-triphosphate (ATP)
Free Images: "bestof:PDB 1g3k EBI.jpg Alpha and beta proteins a+b Ntn hydrolase-like N-terminal nucleophile aminohydrolases Ntn hydrolases Proteasome subunits HslV ClpQ protease EBI"
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